Cov Khoom Lag Luam Wholesale Pure Natural Atractylodes Lancea Roj Rau Kev Lag Luam Tshuaj Txhua Hnub Herb Extract Atractylis Roj

pisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) yog mob qog noj ntshav uas feem ntau tshwm sim ntawm txiv neej thiab poj niam, tshwj xeeb tshaj yog nyob rau hauv Thaib teb. Kev tshawb fawb tsis ntev los no tau qhia tias cov tshuaj ethanol extract ntawm AL muaj cov nyhuv inhibitory rau OV-induced CCA tsiaj qauv yam tsis muaj kev lom zem pom tseeb los ntawm kev noj qhov ncauj rau 30 hnub raws li cov txiaj ntsig los ntawm positron emission tomography-computed tomography thiab txiv neej Syrian hamsters [7]. Txhawm rau tshawb nrhiav qhov cuam tshuam ntawm AL rhizome rau kev txav mus los ntawm lub plab zom mov, cov nas uas tau kho nrog atropine-, dopamine-, thiab 5-hydroxytryptamine (5-HT) tau raug coj los siv rau hauv kev tshawb fawb no. Cov txiaj ntsig tau qhia tias 1 mg/kg extract tuaj yeem tiv thaiv dopamine-induced gastric emptying thiab gastrointestinal motility txo qis los ntawm kev txhaj tshuaj intraperitoneal. Cov extract ntawm qhov concentration ntawm 1000 mg/kg tuaj yeem txwv tsis pub atropine-induced me me intestinal motility txo qis, thiab cov extract ntawm 500 mg/kg koob tshuaj tuaj yeem thaiv 5-HT-induced gastric emptying thiab gastrointestinal motility txo qis [8]. Tsis tas li ntawd, AL muaj cov nyhuv tiv thaiv kab mob gastric ulcer hauv tus qauv nas los ntawm kev txo cov tshuaj inflammatory mediators (piv txwv li tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), thiab prostaglandin E2 (PGE2) thiab nce epidermal growth factor (EGF) thiab trefoil factor2 (TFF2) [9]. Cov kab mob fungal uas kis tau los ntawm av ua rau cov txiv laum huab xeeb tsawg dua 30% [10]. Tsis ntev los no, nws tau tshaj tawm tias kev cog qoob loo nrog cov txiv laum huab xeeb, AL kuj tseem tuaj yeem tiv thaiv cov kab mob fungal uas kis los ntawm av los ntawm kev txwv ntawmKab mob Fusarium oxysporumkev loj hlob [11]. Kev rho tawm roj av ether (PE) los ntawm AL tau qhia txog kev cuam tshuam rau BGC-823 thiab SGC-7901 tib neeg cov hlwb mob qog noj ntshav hauv plab. PE feem tuaj yeem ua rau apoptosis, cell cycle nres, thiab mitochondrial transmembrane hloov pauv [12]. Daim ntawv tshaj tawm tsis ntev los no tau hais tias MeOH extract ntawm AL tuaj yeem tiv thaiv nitric oxide (NO) ntau lawm hauv lipopolysaccharide-stimulated murine macrophage-zoo li RAW264.7 hlwb thiab ua rau granulocyte-colony stimulating factor (G-CSF) secretion hauv murine ib txwm muaj colonic epithelial MCE301 hlwb. NO yog ib qho dawb radical [13]. Cov ethanol extract ntawm AL muaj ib qho tseem ceeb inhibitory effect rau lipase nrog IC50 9.06 µg/mL hauv tib neeg pancreatic lipase assay, thiab tau pom cov nyhuv tiv thaiv kev rog ntawm cov nas rog uas muaj roj ntau ntawm 500 mg/kg [14]. Cov dej rho tawm los ntawm AL tau qhia txog kev ua haujlwm tawm tsam serotonin receptors thiab kev cuam tshuam inhibitory rau cov lus teb ntawm 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane uas ua rau lub taub hau ntswj hauv nas [15]. Cov dej rho tawm los ntawm AL txo cov tshuaj lom los ntawm triptolide los ntawm kev txo qis ntawm kev qhia tawm ntawm lub siab ntawm CYP3A. Lub sijhawm no, AL tuaj yeem txhim kho cov teebmeem tiv thaiv kev o ntawm triptolide. Cov kev tshawb pom no qhia tias AL tuaj yeem tiv thaiv kev lom thiab ua rau muaj kev ua haujlwm kho mob ntawm triptolide los ntawm kev sib xyaw ua ke