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Forsythia suspensa(Thunb.) Vahl. (Tsev neeg Oleaceae) yog ib tsob ntoo cog paj, cov txiv hmab txiv ntoo uas siv los ua TCM "Forsythiae Fructus" (FF) (连翘 hauv Suav). Cov yam ntxwv ntawm TCM ntawm FF yog sau ua lus iab, nrog rau qhov txias me ntsis thiab kev faib tawm ntawm lub ntsws, lub plawv lossis txoj hnyuv (Pharmacopoeia Commission of PRC, 2015), cov yam ntxwv ntawd zoo ib yam li cov yam ntxwv ntawm TCM tiv thaiv kev o, raws li Chen thiab Zhang (2014). Hauv Shennong cov tshuaj ntsuab, FF tau siv rau kev kho mob pyrexia, o, gonorrhea, carbuncle thiab erysipelas (Cho et al., 2011). Muaj ob hom FF, cov txiv hmab txiv ntoo tshiab ntsuab hu ua "Qingqiao" thiab cov txiv hmab txiv ntoo daj siav tag nrho hu ua "Laoqiao". Ob leeg puav leej yog cov chaw tsim tshuaj FF, txawm li cas los xij, Qingqiao siv ntau dua hauv cov ntawv sau tshuaj TCM (Jia et al., 2015). Cov cheeb tsam tsim tshuaj FF tseem ceeb yog Hebei, Shaanxi, Shanxi, Shandong, Anhui, Henan, Hubei, Jiangsu (cog qoob loo) thiab Sichuan Provinces (Editorial Board of Flora of China, 1978).

Xyoo 2015 tsab ntawv xov xwm Suav Pharmacopoeia, muaj 114 hom tshuaj suav uas muaj FF, xws li Shuanghuanglian kua haus, Yinqiao Jiedu ntsiav tshuaj, Niuhuang Shangqing ntsiav tshuaj, thiab lwm yam (Pharmacopoeia Commission of PRC, 2015). Cov kev tshawb fawb niaj hnub no qhia txog nws cov tshuaj tiv thaiv kev o (Kim et al., 2003), tshuaj antioxidant (CC Chen et al., 1999), tshuaj tua kab mob (Han et al., 2012), tshuaj tiv thaiv mob qog noj ntshav (Hu et al., 2007), tshuaj tiv thaiv kab mob (Ko et al., 2005), tshuaj tiv thaiv kev ua xua (Hao et al., 2010), tshuaj tiv thaiv hlwb (S. Zhang et al., 2015) cov teebmeem,lwm yamTxawm hais tias tsuas yog cov txiv hmab txiv ntoo siv ua TCM xwb, qee qhov kev tshawb fawb tau tshaj tawm txog cov phytochemistry thiab pharmacological cov teebmeem ntawm nplooj (Ge et al., 2015, Zhang et al., 2015), paj (Takizawa et al., 1981) thiab noob (Zhang et al., 2002) ntawmF. suspensaYog li ntawd, peb tam sim no muab ib qho kev txheeb xyuas txog cov ntaub ntawv muaj ntawmF. suspensa, suav nrog kev siv ib txwm muaj, kev tshawb fawb txog tsob nroj, phytochemistry, pharmacology, toxicity, pharmacokinetics thiab kev tswj xyuas zoo. Tsis tas li ntawd, cov kev taw qhia yav tom ntej ntawm kev tshawb fawb kuj tau tham txog.

Cov ntu ntawm ntu

Kev siv ib txwm muaj

Hauv cov ntawv sau tshuaj ntsuab Suav qub, FF tau sau tseg tias muaj txiaj ntsig zoo rau kev kho mob ntawm tus nas fistula, scrofula, carbuncle, malignant ulcer, gall tumor, kub thiab lom (Shennong's herbal, Bencao Chongyuan, Bencao Zhengyi, Zhenglei Bencao). Raws li ntau phau ntawv qub, cov tshuaj ntsuab kho mob no muaj txiaj ntsig zoo rau kev tshem tawm qhov kub ntawm lub plawv thiab tso tawm qhov noo noo-kub ntawm lub po thiab plab. Nws kuj tseem kho tau rau kev kho mob stranguria, oedema, qi stagnancy thiab ntshav stasis.

Kev tshawb fawb txog tsob ntoo

F. suspensa(Weeping Forsythia) yog ib tsob ntoo cog ntoo uas zoo nkauj uas loj hlob hauv Suav teb, loj hlob mus txog li 3 m (Daim Duab 1). Nws muaj cov internodes hollow nrog cov ceg nthuav dav lossis pendulous uas yog xim daj-xim av lossis grey-xim av. Cov nplooj feem ntau yog yooj yim, tab sis qee zaum 3-foliolate. Cov nplooj yog ovate, broadly ovate, lossis elliptic-ovate thiab 2–10 × 1.5–5 cm2 loj nrog lub hauv paus puag ncig mus rau cuneate thiab lub apex ntse. Ob sab ntawm cov nplooj yog ntsuab, glabrous nrog ntse lossis coarsely.

Cov tshuaj lom neeg

Niaj hnub no, muaj 237 cov tshuaj sib xyaw tau pom nyob rau hauvF. suspensa, suav nrog 46 lignans (1–46), 31 phenylethanoid glycosides (47–77), 11 flavonoids (78–88), 80 terpenoids (89–168), 20 cyclohexylethanol derivatives (169–188), rau alkaloids (189–194), plaub steroids (195–198) thiab 39 lwm yam tshuaj (199–237). Ntawm lawv, ob yam khoom (21–22) tau rho tawm los ntawm cov paj ntawmF. suspensa, 19 yam khoom (94–100, 107–111, 115–117, 198, 233–235) tau raug rho tawm ntawm nplooj ntawmF. suspensa, plaub yam khoom sib xyaw

Cov teebmeem tiv thaiv kev o

Cov dej num tiv thaiv kev o ntawm FF txhawb nqa nws cov teebmeem tshem tawm cua sov (Guo et al., 2015). Kev o yog kev teb lub cev rau kev sib kis, kev ua xua, lossis kev txhawb nqa tshuaj lom neeg (Lee et al., 2011). Nws koom nrog kev txhim kho cov kab mob ntev, xws li kab mob ntawm daim tawv nqaij, kev ua xua, thiab mob qog noj ntshav,lwm yamFF yog ib qho ntawm TCM nrog lub peev xwm tiv thaiv kev o, nws yog dav siv rau kev mob o ntev thiab mob hnyav. Cov dej num tiv thaiv kev o ntawm FF tau qeb duas sab saum toj tsib ntawm 81 qhov kev sim TCM (70% ethanol

Kev lom

Txog rau tam sim no, tseem tsis tau muaj daim ntawv qhia txog kev lom ntawm FF. Kev noj tshuaj txhua hnub ntawm FF yog pom zoo kom yog 6-15 g (Pharmacopoeia Commission ntawm PRC, 2015). Cov ntawv qhia cuam tshuam qhia tias tsis muaj kev lom ntawm dej lossis ethanol extract ntawm nplooj ntawmF. suspensahauv nas, txawm tias ntawm cov koob tshuaj txhua hnub ntawm 61.60 g / kg (Ai et al., 2011, Hou et al., 2016, Li et al., 2013). Han et al. (2017) tau tshaj tawm tsis muaj kev lom tshuaj ntawm phillyrin (los ntawm nplooj ntawmF. suspensa)hauv cov nas NIH (18.1 g/kg/hnub, po, rau 14 hnub) lossis tsis muaj

Kev tshuaj lom neeg

Li et al. tau txheeb xyuas cuaj theem I metabolites ntawm phillyrin hauv cov qauv zis ntawm cov nas thiab tau nthuav tawm nws cov txheej txheem metabolic uas ua tau hauv cov nas. Phillyrin tau pib hydrolyzed rau hauv phillygenin thiab tom qab ntawd hloov mus rau lwm cov metabolites los ntawm kev methylation, demethylation, dehydroxylation thiab cov txheej txheem qhib lub nplhaib (Li et al., 2014c). H. Wang et al. (2016) tau txheeb xyuas 34 theem I thiab theem II metabolites ntawm phillyrin thiab qhia tias hydrolysis, oxidation thiab sulfation yog qhov tseem ceeb

Kev tswj xyuas zoo

Txhawm rau tswj qhov zoo ntawm FF, Suav Pharmacopoeia qhia txog morphological, microscopic thiab TLC kev txheeb xyuas ntxiv rau kev txiav txim siab HPLC. Cov qauv FF tsim nyog yuav tsum muaj ntau dua 0.150% phillyrin (Pharmacopoeia Commission ntawm PRC, 2015).

Txawm li cas los xij, ib qho cim qhia txog kev ntsuas ntau npaum li cas, phillyrin, zoo li tsis txaus los ntsuas qhov zoo ntawm FF. Tsis ntev los no, ntau yam khoom siv bioactive hauv FF tau kuaj xyuas los ntawm cov txheej txheem chromatography, electrophoresis, MS thiab NMR, xws li

Xaus lus thiab kev xav yav tom ntej

Cov kev tshuaj xyuas tam sim no sau cov ntaub ntawv qhia txog kev siv ib txwm muaj, botany, phytochemistry, cov teebmeem tshuaj, kev lom, pharmacokinetics thiab kev tswj xyuas zoo ntawmF. suspensaHauv cov ntawv sau tshuaj ntsuab Suav thiab cov ntawv sau tshuaj suav, FF feem ntau yog siv rau kev tshem tawm kub thiab tshem tawm cov tshuaj lom. Txog tam sim no, ntau dua 230 cov tshuaj tau raug cais thiab txheeb xyuas los ntawm cov tshuaj ntsuab no. Ntawm lawv, lignans thiab phenylethanoid glycosides raug suav hais tias yog cov yam ntxwv thiab bioactive.

Cov lus txhais ntawm TCM

Yin: "Yin" yog ib qho ntawm ob lub zog sib txawv ntawm xwm, raws li kev tsim ntawm lub ntiaj teb Suav thaum ub. "Yin" yog tus cwj pwm qeeb, mos, tso zis, sib txawv, txias, ntub lossis ntsiag to, thiab nws yog txuam nrog dej, av, lub hli, poj niam thiab hmo ntuj.

Qi: Hauv cov lus acupuncture, "qi" yog "lub zog ua neej". Nws yog qhov chaw ntawm txhua yam kev txav mus los hauv lub cev, kev tiv thaiv kev nkag mus rau hauv lub cev, qhov chaw ntawm txhua yam kev ua ub no ntawm lub cev, muab kev tuav cov ntaub so ntswg.

Cov Lus Ua Tsaug

Txoj haujlwm no tau txais kev txhawb nqa los ntawm Beijing Joint Project of Science Research nrog kev kawm tiav qib siab - Kev tshawb fawb txog thev naus laus zis tseem ceeb thiab kev siv kev ntsuam xyuas kev nyab xeeb ntawm cov khoom siv tshuaj lom neeg Suav raws li cov tshuaj lom neeg thiab cov yam ntxwv ntawm zebrafish.

Nqe FOB:Teb Chaws Asmeskas $0.5 - 9,999 / Daim

Min.Order Quantity:100 Daim / Daim

Kev Muaj Peev Xwm Muab Khoom:10000 Daim / Daim Ib Hlis

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Cov Khoom Qhia Txog Khoom

Cov Cim Npe Khoom

Qhov cuam tshuam ntawm Ethnopharmacological

Forsythiae Fructus (hu ua Lianqiao hauv Suav), txiv hmab txiv ntoo ntawmForsythia suspensa(Thunb.) Vahl, yog siv ua tshuaj ib txwm muaj nyob rau hauv Suav teb, Nyiv Pooj thiab Kauslim Teb. Nws yog ib txwm siv los kho mob pyrexia, o,kab mob gonorrhea,mob pob khausthiabmob erysipelasNyob ntawm lub sijhawm sau qoob loo sib txawv, Forsythiae Fructus muaj ob hom, uas yog Qingqiao thiab Laoqiao. Cov txiv ntsuab uas pib siav raug sau ua Qingqiao, thaum cov txiv daj uas siav tag lawm raug sau ua Laoqiao. Ob qho tib si siv rau kev siv kho mob. Daim ntawv tshuaj xyuas no lub hom phiaj yog los muab kev sau luv luv txogF. suspensa(Forsythia suspensa(Thunb.) Vahl) thiab los qhia txog kev sib raug zoo ntawm kev siv ib txwm muaj thiabkev ua haujlwm tshuajyog li ntawd los muab kev tshoov siab rau kev tshawb fawb yav tom ntej.

Cov ntaub ntawv thiab cov txheej txheem

Txhua cov ntaub ntawv sib xws txogF. suspensatau tshawb nrhiav los ntawm Scifinder thiab tau txais los ntawm cov ntaub ntawv tshawb fawb suav nrog Springer, Science Direct, Wiley, Pubmed thiab China Knowledge Resource Integrated (CNKI). Cov ntawv sau thiab cov phau ntawv hauv zos kuj tau tshawb nrhiav thiab.

Cov txiaj ntsig

Raws li cov ntawv sau tshuaj ntsuab Suav thiab Pharmacopoeia Suav, Forsythiae Fructus feem ntau qhia txog kev tshem tawm cua sov thiab kev tshem tawm cov tshuaj lom hauvTCMcov ntawv sau tshuaj. Hauv kev tshawb fawb niaj hnub no, ntau dua 230 cov tshuaj tau raug cais thiab txheeb xyuas los ntawmF. suspensa. 211 Ntawm lawv tau cais tawm ntawm cov txiv hmab txiv ntoo.Cov Lignansthiab phenylethanoidcov glycosidesraug suav hais tias yog cov yam ntxwv thiab cov khoom xyaw nquag ntawm cov tshuaj ntsuab no, xws li forsythiaside, phillyrin,rutinthiab phillygenin. Lawv tau ua pov thawj tias muaj cov teebmeem tiv thaiv kev o, antioxidant, antibacterial, anti-virus, anti cancer thiab anti-allergy,lwm yamTam sim no, tsis muaj daim ntawv qhia txog kev lom ntawm Forsythiae Fructus, txawm hais tias muaj kev lom me ntsis ntawm forsythiaside tau tshaj tawm hauv cov ntawv tshaj tawm hauv zos. Piv rau Laoqiao, Qingqiao muaj cov forsythiaside, forsythoside C, cornoside ntau dua,rutin, phillyrin,gallic acidthiabchlorogenic acidthiab cov theem qis dua ntawm rengyol,β-glucose thiab S-suspensasidemethyl ether.

Xaus lus

Kev ua kom sov ntawm Forsythiae Fructus yog raws li cov khoom tiv thaiv kev o thiab antioxidant ntawm lignans thiab phenylethanoid.cov glycosidesCov txiaj ntsig ntawm kev tshem tawm cov tshuaj lom yog vim muaj cov tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob qog noj ntshav ntawm Forsythiae Fructus. Thiab cov yam ntxwv ntawm tshuaj suav Suav (TCM) ntawm Forsythiae Fructus (qab iab, txias me ntsis thiab lub ntsws meridian) txhawb nqa nws cov txiaj ntsig tiv thaiv kev o. Tsis tas li ntawd, cov tshuaj tiv thaiv kev o thiabmuaj peev xwm tiv thaiv kab mob antioxidantntawm Forsythiae Fructus pab txhawb rau nws cov tshuaj tiv thaiv kab mob thiabtiv thaiv cov hlab ntsha hlwbcov dej num. Qhov feem pua ntau ntawm lignans thiab phenylethanoid glycosides hauv Qingqiao dua li Laoqiao tej zaum yuav piav qhia txog lub peev xwm antioxidant zoo dua ntawm Qingqiao thiab kev siv ntau dua ntawm Qingqiao hauvTCMcov tshuaj. Rau kev tshawb fawb yav tom ntej, ntau ntxivnyob rau hauv lub cevCov kev sim thiab kev tshawb fawb hauv tsev kho mob raug txhawb kom ua kom meej ntxiv txog kev sib raug zoo ntawm kev siv ib txwm muaj thiab kev siv niaj hnub no. Hais txog Qingqiao thiab Laoqiao, lawv tseem yuav tsum tau sib txawv los ntawm txhua txoj kev tswj xyuas zoo, thiab cov tshuaj lom neeg thiab cov teebmeem hauv tsev kho mob ntawm lawv yuav tsum tau muab piv.