OEM Custom Package Natural Macrocephalae Rhizoma roj

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Raws li kev siv tshuaj khomob zoo, 5-fluorouracil (5-FU) tau siv dav rau kev kho mob qog nqaij hlav hauv plab hnyuv, taub hau, caj dab, hauv siab, thiab zes qe menyuam. Thiab 5-FU yog thawj kab tshuaj rau mob qog noj ntshav hauv tsev kho mob. Lub luag haujlwm ntawm 5-FU yog los thaiv kev hloov pauv ntawm uracil nucleic acid rau hauv thymine nucleic acid hauv cov qog hlwb, tom qab ntawd cuam tshuam rau kev sib txuas thiab kho DNA thiab RNA kom ua tiav nws cov nyhuv cytotoxic (Afzal li al., 2009; Ducreux et al., 2015; Longley et al., 2003). Txawm li cas los xij, 5-FU kuj tsim cov tshuaj kho mob raws plab (CID), ib qho ntawm cov kev tsis zoo tshwm sim uas ua rau ntau tus neeg mob (Filho et al., 2016). Qhov tshwm sim ntawm kev mob raws plab hauv cov neeg mob kho nrog 5-FU yog nce txog 50% -80%, uas cuam tshuam rau kev nce qib thiab kev ua tau zoo ntawm kev kho mob (Iacovelli li al., 2014; Rosenoff li al., 2006). Yog li ntawd, nws yog ib qho tseem ceeb kom nrhiav tau txoj kev kho mob zoo rau 5-FU induced CID.

Tam sim no, cov kev cuam tshuam uas tsis yog tshuaj yeeb tshuaj thiab cov tshuaj cuam tshuam tau raug xa mus rau hauv kev kho mob ntawm CID. Cov tshuaj tsis siv tshuaj muaj xws li kev noj zaub mov kom tsim nyog, thiab ntxiv nrog ntsev, qab zib thiab lwm yam khoom noj. Cov tshuaj xws li loperamide thiab octreotide feem ntau yog siv rau kev kho mob raws plab ntawm CID (Benson li al., 2004). Tsis tas li ntawd, ethnomedicines kuj tau txais los kho CID nrog lawv tus kheej txoj kev kho tshwj xeeb hauv ntau lub tebchaws. Cov tshuaj suav tshuaj (TCM) yog ib hom tshuaj ethnomedicine uas tau siv rau ntau tshaj 2000 xyoo hauv East Asian lub teb chaws suav nrog Tuam Tshoj, Nyiv thiab Kaus Lim Kauslim (Qi li al., 2010). TCM tuav cov tshuaj chemotherapeutic yuav ua rau Qi noj, spleen deficiency, plab disarmony thiab endophytic dampness, uas ua rau conductive dysfunction ntawm hnyuv. Hauv TCM txoj kev xav, txoj kev kho mob ntawm CID yuav tsum yog nyob ntawm kev ntxiv Qi thiab ntxiv dag zog rau tus po (Wang li al., 1994).

Cov cag qhuav ntawmAtractylodes macrocephalaKoidz. (AM) thiabPanax ginseng tshuajCA Mey. (PG) yog cov tshuaj ntsuab nyob rau hauv TCM nrog tib cov teebmeem ntawm supplementing Qi thiab ntxiv dag zog rau tus po (Li et al., 2014). AM thiab PG feem ntau yog siv los ua tshuaj ntsuab khub (qhov yooj yim tshaj plaws ntawm Suav tshuaj ntsuab compatibility) nrog cov teebmeem ntawm supplementing Qi thiab ntxiv dag zog rau tus po los kho raws plab. Piv txwv li, AM thiab PG tau sau tseg hauv cov qauv tshuaj tiv thaiv kab mob raws plab xws li Shen Ling Bai Zhu San, Si Jun Zi Tang los ntawmTaiping Huimin Heji Ju Fang(Song dynasty, Tuam Tshoj) thiab Bu Zhong Yi Qi Tang los ntawmPi Wei Lun(Yuan dynasty, Suav teb) (Fig. 1). Ntau qhov kev tshawb fawb yav dhau los tau tshaj tawm tias tag nrho peb cov qauv muaj peev xwm txo tau CID (Bai li al., 2017; Chen li al., 2019; Gou et al., 2016). Tsis tas li ntawd, peb txoj kev tshawb fawb yav dhau los tau pom tias Shenzhu Capsule uas tsuas muaj AM thiab PG muaj peev xwm cuam tshuam rau kev kho mob raws plab, colitis (xiexie syndrome), thiab lwm yam kab mob hauv plab (Feng li al., 2018). Txawm li cas los xij, tsis muaj kev tshawb fawb tau tham txog cov txiaj ntsig thiab cov txheej txheem ntawm AM thiab PG hauv kev kho CID, txawm tias ua ke lossis ib leeg.

Tam sim no lub plab microbiota tau suav tias yog qhov tseem ceeb hauv kev nkag siab txog kev kho mob ntawm TCM (Feng li al., 2019). Cov kev tshawb fawb niaj hnub no qhia tias plab microbiota ua lub luag haujlwm tseem ceeb hauv kev tswj cov hnyuv homeostasis. Noj qab nyob zoo plab microbiota pab txhawb txoj hnyuv mucosal tiv thaiv, metabolism, tiv thaiv homeostasis thiab teb, thiab kab mob tsub kom (Thursby thiab Juge, 2017; Pickard li al., 2017). Disordered plab microbiota impairs lub physiological thiab kev tiv thaiv kev ua hauj lwm ntawm tib neeg lub cev ncaj qha los yog indirectly, inducing sab kev xav xws li raws plab (Patel li al., 2016; Zhao thiab Shen, 2010). Cov kev tshawb fawb tau pom tias 5-FU zoo kawg nkaus hloov cov qauv ntawm plab microbiota hauv cov nas raws plab (Li et al., 2017). Yog li, cov teebmeem ntawm AM thiab PM ntawm 5-FU ua rau raws plab tuaj yeem kho los ntawm plab hnyuv microbiota. Txawm li cas los xij, txawm tias AM thiab PG ib leeg thiab ua ke tuaj yeem tiv thaiv 5-FU ua rau raws plab los ntawm kev hloov cov plab hnyuv microbiota tseem tsis tau paub.

Txhawm rau tshawb xyuas qhov cuam tshuam los tiv thaiv kab mob plab thiab lub hauv paus txheej txheem ntawm AM thiab PG, peb siv 5-FU los simulate tus qauv raws plab hauv cov nas. Ntawm no, peb tsom mus rau qhov muaj feem cuam tshuam ntawm kev tswj hwm ib leeg thiab ua ke (AP) ntawmAtractylodes macrocephalatseem ceeb roj (AMO) thiabPanax ginseng tshuajtag nrho cov saponins (PGS), cov khoom siv ua haujlwm raws li tau muab rho tawm los ntawm AM thiab PG, ntawm raws plab, plab hnyuv pathology thiab microbial qauv tom qab 5-FU chemotherapy.

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Ethnopharmacological qhov tseeb

Cov tshuaj suav tshuaj(TCM) tuav tau tias qhov tsis txaus ntawm tus po-Qi yog qhov tseem ceeb ntawm kev kho mob raws plab (CID). Tshuaj ntsuab khubAtractylodesmacrocephalaKoidz. (AM) thiabPanax ginseng tshuajCA Mey. (PG) muaj cov txiaj ntsig zoo ntawm kev ntxiv Qi thiab ntxiv dag zog rau tus po.

Lub hom phiaj ntawm kev kawm

Txhawm rau tshawb xyuas cov teebmeem kho mob thiab cov txheej txheem ntawmAtractylodes macrocephalatseem ceeb roj (AMO) thiabPanax ginseng tshuajtag nrhosaponins(PGS) ib leeg thiab ua ke (AP) ntawm 5-fluorouracil (5-FU) chemotherapy induced raws plab hauv cov nas.

Cov ntaub ntawv thiab cov txheej txheem

Cov nas tau muab tshuaj nrog AMO, PGS thiab AP raws li 11 hnub, thiab txhaj tshuaj intraperitoneally nrog 5-FU rau 6 hnub txij li hnub thib 3 ntawm qhov kev sim. Thaum lub sij hawm sim, lub cev hnyav thiab raws plab cov qhab nia ntawm nas tau sau txhua hnub. Thymus thiab spleen indexes tau suav tom qab kev txi ntawm cov nas. Pathological hloov nyob rau hauv ileum thiab colonic cov ntaub so ntswg raug soj ntsuam los ntawm hematoxylin-eosin (HE) staining. Thiab cov ntsiab lus theem ntawm plab hnyuv cytokines raug ntsuas los ntawm enzyme-linked immunosorbent assays (ELISA).16S rDNAAmplicon Sequencing tau siv los txheeb xyuas thiab txhais cov lusplab microbiotantawm fecal kuaj.

Cov txiaj ntsig

AP cuam tshuam lub cev hnyav poob, raws plab, txo qis ntawm thymus thiab spleen indexes, thiab kev hloov pauv pathological ntawm ileums thiab colons induced los ntawm 5-FU. Tsis yog AMO lossis PGS ib leeg tau txhim kho qhov txawv txav saum toj no. Tsis tas li ntawd, AP tuaj yeem cuam tshuam qhov 5-FU-mediated nce ntawm txoj hnyuv inflammatory cytokines (TNF-α, IFN-γ, ib-6, IL-1βthiab IL-17), thaum AMO lossis PGS tsuas yog txwv qee qhov ntawm lawv tom qab 5-FU chemotherapy. Gut microbiota tsom xam qhia tias 5-FU induced tag nrho cov qauv kev hloov ntawmplab microbiotatau thim rov qab tom qab kev kho mob AP. Tsis tas li ntawd, AP tau hloov kho qhov kev nplua nuj ntawm cov phyla sib txawv zoo ib yam li cov txiaj ntsig ib txwm muaj, thiab rov kho qhov sib piv ntawmFirmicutes/Bacteroidetes(F/B). Ntawm qib genus, AP kev kho mob txo qis cov kab mob zoo liBacteroides,Ruminococcus,Anaerotruncus nyob rau hauv cov me nyuamthiabDesulfovibrio. AP kuj tau tawm tsam qhov txawv txav ntawm AMO thiab PGS ib leeg ntawm qee yam zoo liBlautia,ParabacteroidesthiabLactobacillus. Tsis yog AMO lossis PGS ib leeg inhibited kev hloov ntawm lub plab microbial qauv tshwm sim los ntawm 5-FU.