Ntshiab Artemisia capillaris roj rau tswm ciab thiab xab npum ua lag luam wholesale diffuser tseem ceeb roj tshiab rau reed burner diffusers

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Rodent qauv tsim

Cov tsiaj tau muab faib ua tsib pawg ntawm kaum tsib nas txhua. Pawg tswj hwm thiab cov qauv pab pawg nas tau muab faib nrognoob rojrau 6day. Cov pab pawg tswj tau zoo tau muab tshuaj nrog bifendate ntsiav tshuaj (BT, 10 mg / kg) rau 6 hnub. Cov pab pawg sim tau raug kho nrog 100 mg / kg thiab 50 mg / kg AEO yaj hauv cov roj noob hnav rau 6 hnub. Hnub 6, pawg tswj hwm tau kho nrog cov roj noob hnav, thiab tag nrho lwm pab pawg tau kho nrog ib koob tshuaj ntawm 0.2% CCl4 hauv cov roj noob hnav (10 ml / kg) los ntawmtxhaj tshuaj intraperitoneal. Cov nas tau yoo mov tsis muaj dej, thiab cov ntshav tau sau los ntawm cov hlab ntsha retrobulbar; cov ntshav sau tau centrifuged ntawm 3000 ×grau 10 feeb kom cais cov ntshav.Cervical dislocationtau ua tiav tam sim ntawd tom qab tshem tawm cov ntshav, thiab kuaj lub siab raug tshem tawm sai. Ib feem ntawm daim siab tus qauv tau muab khaws cia tam sim ntawm -20 ° C kom txog thaum kev soj ntsuam, thiab lwm qhov yog excised thiab kho hauv 10%formalindaws; cov ntaub so ntswg ntxiv tau khaws cia ntawm -80 ° C rau kev tshuaj xyuas histopathological (Wang et al., 2008,Hsu et al., 2009,Nie et al., 2015).

Kev ntsuas ntawm biochemical tsis nyob hauv cov ntshav

Kev raug mob lub siab raug ntsuas los ntawm kev kwv yeeskev ua haujlwm enzymaticntawm cov ntshav ALT thiab AST siv cov khoom siv coj mus muag raws li cov lus qhia rau cov khoom siv (Nanjing, Jiangsu Province, Suav). Cov dej num enzymatic tau qhia ua units ib liter (U / l).

Kev ntsuas ntawm MDA, SOD, GSH thiab GSH-Pxhauv daim siab homogenates

Lub siab cov ntaub so ntswg tau homogenized nrog txias physiological saline ntawm 1: 9 piv (w / v, siab: saline). Cov homogenates tau centrifuged (2500 ×grau 10 min) los sau cov supernatants rau qhov kev txiav txim tom ntej. Lub siab puas tsuaj tau raug soj ntsuam raws li kev ntsuas kab mob siab ntawm MDA thiab GSH qib nrog rau SOD thiab GSH-Pxkev ua si. Tag nrho cov no tau txiav txim siab ua raws li cov lus qhia ntawm cov khoom siv (Nanjing, Jiangsu Province, Suav). Cov txiaj ntsig rau MDA thiab GSH tau qhia raws li nmol ib mg protein (nmol / mg prot), thiab cov dej num ntawm SOD thiab GSH-Pxtau qhia raws li U per mg protein (U / mg prot).

Kev txheeb xyuas histopathological

Ib feem ntawm lub siab tau txais tshiab tau kho nyob rau hauv 10% bufferedparaformaldehydephosphate daws. Tom qab ntawd cov qauv tau muab tso rau hauv paraffin, hlais rau hauv 3-5 μm ntu, stained nroghematoxylinthiabeosin ua(H&E) raws li tus txheej txheem txheej txheem, thiab thaum kawg soj ntsuam los ntawmlub teeb microscopy(Tian et al., 2012).

Kev txheeb cais

Cov txiaj ntsig tau qhia raws li qhov nruab nrab ± tus qauv sib txawv (SD). Cov txiaj ntsig tau raug tshuaj xyuas los ntawm kev siv cov ntaub ntawv txheeb cais SPSS Statistics, version 19.0. Cov ntaub ntawv tau raug soj ntsuam ntawm qhov sib txawv (ANOVA,p<0.05) ua raws li Dunnett's test thiab Dunnett's T3 test los txiav txim siab qhov sib txawv ntawm cov txiaj ntsig ntawm ntau pawg sim. Qhov sib txawv tseem ceeb tau txiav txim siab nyob rau theem ntawmp<0.05 Nws.

Cov txiaj ntsig thiab kev sib tham

Cov ntsiab lus ntawm AEO

Raws li GC / MS tsom xam, AEO tau pom tias muaj 25 tus neeg sawv cev tawm ntawm 10 mus rau 35 min, thiab 21 tus neeg suav nrog 84% ntawm cov roj tseem ceeb tau txheeb xyuas (Table 1). Cov roj volatile muajmonoterpenoids(80.9%), sesquiterpenoids (9.5%), saturated unbranched hydrocarbons (4.86%) thiab lwm yam acetylene (4.86%). Piv nrog rau lwm cov kev tshawb fawb (Guo et al., 2004), peb pom muaj ntau monoterpenoids (80.90%) hauv AEO. Cov txiaj ntsig tau pom tias feem ntau cov ntsiab lus ntawm AEO yog β-citronellol (16.23%). Lwm yam tseem ceeb ntawm AEO suav nrog 1,8-cineole (13.9%),camphor(12.59%),linalool(11.33%), α-pinene (7.21%), β-pinene (3.99%),thymol(3.22%), thiabmyrcene(2.02%). Qhov sib txawv ntawm cov tshuaj muaj pes tsawg leeg yuav muaj feem xyuam rau ib puag ncig tej yam kev mob uas cov nroj tsuag raug, xws li ntxhia dej, tshav ntuj, theem ntawm kev loj hlob thiabkhoom noj khoom haus.

FOB Nqe:US $0.5 - 9,999 / Daim

Min. Order Quantity:100 Daim / Daim

Muaj peev xwm muab khoom:10000 Daim / Daim ib lub hli

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Khoom cim npe

Kab mob siab, ib yam kab mob tshwm sim los ntawmkab mob siabKev haus dej cawv, tshuaj lom neeg lub siab, kev noj zaub mov tsis zoo thiab kev ua qias tuaj ib puag ncig, yog ib qho kev txhawj xeeb thoob ntiaj teb (Papay et al., 2009). Txawm li cas los xij, kev kho mob rau tus kab mob no feem ntau nyuaj rau kev tswj hwm thiab muaj kev txwv. Tsoos suavtshuaj ntsuab, uas underlie ntau cov tshuaj siv los kho cov kab mob siab, tseem siv dav los ntawm Suav (Zhao et al., 2014).Artemisia capillarisThunb.,Asteraceae, raws li Bencao Gangmu, cov ntaub ntawv nto moo tshaj plaws ntawm Suav Tshuaj Kho Mob, tau siv dav los ua cov tshuaj kom tshem tawm cov cua sov, txhawb nqa.diuresisthiab tshem tawm jaundice thiab kuj tau siv los ua ib qho tsw hauv dej haus, zaub, thiab pastries vim nws cov ntxhiab tsw.A. capillaristau raug suav tias yog hom tshuaj suav pej xeem thiab zaub mov los ntawm cov neeg coob coob. Yog li ntawd, tau muaj kev siv zog ntau los tsim cov tshuaj ntsuab muaj txiaj ntsig, xws liA. capillaris, rau kev kho mob siab.

Nyob rau hauv xyoo tas los no, cov tshuaj ntsuab tau txais kev saib xyuas ntau dua thiab muaj koob meej rau kev kho mob ntawm daim siab vim lawv txoj kev nyab xeeb thiab kev ua tau zoo (Ding et al., xyoo 2012).A. capillaristau raug pov thawj tias muaj kev ua haujlwm zoo hepatoprotective raws li niaj hnub pharmacological txoj kev (Han et al., xyoo 2006). Nws kuj yog ib qho tseem ceeb tshuaj siv nyob rau hauv Tuam Tshoj thiab yog ib tug nrov anti-inflammatory (Cha et al., 2009a),choleretic(Yoon and Kim, 2011), thiab anti-tumor (Feng et al., 2013)tshuaj ntsuab.

PhytochemicalCov kev tshawb fawb tau qhia ntau yam tsis muaj roj yam tseem ceeb,coumarins, thiabflavonol glycosidesnrog rau ib pab pawg neeg uas tsis paubaglyconeslos ntawmA. capillaris(Komiya et al., 1976,Yamahara et al., 1989). Qhov tseem ceeb roj ntawmA. capillaris(AEO) yog ib qho ntawm cov tshuaj tseem ceeb ntawm cov tshuaj nquag thiab ua rau muaj kev tiv thaiv kab mob (Cha et al., 2009athiab anti-apoptotic zog (Cha et al., 2009b). Txawm li cas los xij, raws li AEO yog ib qho ntawm cov ntsiab lus tseem ceeb ntawmA. capillaris, lub peev xwm hepatoprotective kev ua ub no ntawm cov khoom tseem ceeb los ntawmA. capillarisyuav tsum tau tshawb nrhiav.

Hauv txoj kev tshawb no, kev tiv thaiv ntawm AEO raucarbon tetrachloride(CCl4)-inducedhepatotoxicitytau soj ntsuam los ntawm cov txheej txheem biochemical, xws li kab mob siabtxo glutathione(GSH),malondialdehydeQib (MDA),superoxide dismutase(SOD), thiabglutathione peroxidase(GSH-Px) kev ua haujlwm, nrog rau cov haujlwm ntawmaspartate aminotransferase(AST) thiabalanine aminotransferase(ALT) hauv cov ntshav. Qhov luaj li cas ntawm CCl4-vim lub siab raug mob kuj tau txheeb xyuas los ntawm kev soj ntsuam histopathological, nrog rau kev tshuaj xyuas phytochemical los ntawm GC-MS txhawm rau txheeb xyuas cov ntsiab lus ntawm AEO.