Qhov tseem ceeb roj tej Hoobkas | Tuam Tshoj Essential roj tej hub Manufacturers thiab lwm tus neeg

Lag luam wholesale Ntshiab Ntuj Atractylodes Lancea Roj rau Txhua Hnub Kev Lag Luam Tshuaj Tshuaj Ntsuab Extract Atractylis Roj

KEV PAB CUAM THIAB COV NTAUB NTAWV: Cov ntaub ntawv no yog tsim los ntxiv, tsis yog hloov cov lus qhia los ntawm koj tus kws kho mob lossis tus kws kho mob thiab tsis yog txhais tau hais tias yuav siv tau, ceev faj, cuam tshuam lossis cuam tshuam. Cov ntaub ntawv no yuav tsis haum rau koj qhov xwm txheej tshwj xeeb. Tsis txhob ncua lossis tsis quav ntsej txog kev nrhiav kev qhia txog kev kho mob los ntawm koj tus kws kho mob lossis lwm tus kws kho mob uas tsim nyog vim yog qee yam koj tau nyeem hauv WebMD. Koj yuav tsum nrog koj tus kws kho mob lossis tus kws kho mob tham ua ntej koj pib, nres, lossis hloov ib feem ntawm koj txoj kev npaj kho mob lossis kev kho mob thiab txiav txim siab seb txoj kev kho mob twg yog qhov zoo rau koj.

Cov ntaub ntawv pov thawj no yog muab los ntawm Natural Medicines Comprehensive Database Consumer Version. Cov ntaub ntawv los ntawm qhov chaw no yog pov thawj-raws li thiab lub hom phiaj, thiab tsis muaj kev lag luam cuam tshuam. Rau cov ntaub ntawv kho mob tshaj lij ntawm cov tshuaj ntuj, saib Natural Medicines Comprehensive Database Professional Version.

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Lag luam wholesale Ntshiab Ntuj Atractylodes Lancea Roj rau Txhua Hnub Kev Lag Luam Tshuaj Tshuaj Ntsuab Extract Atractylis Roj

Atractylodes lancea cag extract yog dab tsi?

Atractylodes lancea yog Suav keeb kwm, cov nroj tsuag muaj txiaj ntsig zoo, uas yog cog rau nws cov rhizomes. Nws cov rhizomes muaj cov roj yam tseem ceeb.

Siv & Cov txiaj ntsig:

Nws muaj anti-inflammatory zog, nws soothes ntawm daim tawv nqaij thaum thov. Nws yuav pab tau rau pob txuv, khaus tawv nqaij.

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Menthol CamphorBorneol roj Cov ntsiab lus rau Da Dej Thiab Aromatherapy
Cov txiaj ntsig kev noj qab haus huv thiab kev siv

Borneol muab kev sib tshuam zoo heev ntawm Western thiab Eastern tshuaj. Cov nyhuv ntawm Borneol yog dav hauv kev kho mob ntawm ntau yam kab mob. Hauv Suav Tshuaj, nws cuam tshuam nrog lub siab, spleen meridians, lub plawv, thiab lub ntsws. Hauv qab no yog cov npe ntawm qee qhov ntawm nws cov txiaj ntsig kev noj qab haus huv ntau.

Tiv thaiv kab mob ua pa thiab mob ntsws

Ntau cov kev tshawb fawb qhia tias terpenes, thiab Borneol, tshwj xeeb, txo cov mob ua pa. Borneol muajua kom pom kev ua tau zoonyob rau hauv txo o ntawm lub ntsws los ntawm kev txo cov inflammatory cytokines thiab inflammatory infiltration. Cov tib neeg xyaum suav tshuaj kuj feem ntau siv Borneol los kho bronchitis thiab cov kab mob zoo sib xws.

Anticancer zog

Borneol kuj tau ua qauv qhiaanticancer zoglos ntawm kev nce qhov kev txiav txim ntawm Selenocysteine (SeC). Qhov no txo qis mob qog noj ntshav los ntawm apoptotic (programmed) mob qog noj ntshav cell tuag. Hauv ntau cov kev tshawb fawb, Borneol kuj tau pom tias muaj kev ua tau zoo ntawmantitumor tshuaj aiming.

Cov nyhuv analgesic

Hauv ibkawmxav txog kev mob tom qab phais hauv tib neeg, tshuaj pleev Borneol daim ntawv thov ua rau txo qhov mob tseem ceeb piv rau pawg placebo tswj. Tsis tas li ntawd, acupuncturists nyiam siv Borneol topically rau nws cov khoom noj tshuaj.

Anti-inflammatory kev ua

Borneol muajua qauv qhiathaiv qee cov ion channel uas txhawb kev mob stimulus thiab o. Nws kuj pab nyob rau hauv qhov mob nyem los ntawm inflammatory kab mob xws limob caj dab rheumatoid.

Cov teebmeem Neuroprotective

Borneol muaj qee qhov kev tiv thaiv los ntawmneuronal cell tuagnyob rau hauv cov xwm txheej ntawm ischemic stroke. Nws kuj pab txhawb kev tsim kho ntawm lub hlwb thiab kho. Nws tau thov kom muaj qhov cuam tshuam neuroprotective los ntawm kev hloov cov permeability ntawm covntshav-hlwb barrier.

Fights kev ntxhov siab thiab qaug zog

Qee cov neeg siv cov kab mob cannabis uas muaj ntau dua Borneol qhia tias nws txo lawv cov kev ntxhov siab thiab txo qis kev nkees, yog li, tso cai rau lub xeev ntawm kev so tsis muaj kev ntxhov siab. Cov tib neeg uas xyaum suav tshuaj kuj lees paubnws txoj kev ntxhov siab nyem potential.

Entourage effect

Raws li nrog rau lwm cov terpenes, cov teebmeem ntawm Borneol ua ke nrog cov cannabinoids ntawm cannabis tau ua pov thawj tiasentourage nyhuv.Qhov no tshwm sim thaum cov tebchaw ua haujlwm ua ke los muab qee qhov txiaj ntsig kho mob siab. Borneol tuaj yeem ua rau cov ntshav-hlwb barrier permeability, tso cai rau kev yooj yim dua ntawm kev kho cov molecules mus rau hauv nruab nrab paj hlwb.

Ib cag los ntawm Borneol ntau cov ntawv siv tshuaj, nws kuj yog siv rau hauv tshuaj tua kab vim nws lub ntuj toxicity rau ntau kab. Perfumeries kuj siv Borneol rau nws cov ntxhiab tsw qab ntxiag rau tib neeg.

Muaj peev xwm txaus ntshai thiab cov teebmeem tshwm sim

Borneol feem ntau suav hais tias yog qhov thib ob terpene hauv cannabis, txhais tau tias nws tshwm sim hauv cov nyiaj me me. Cov koob tshuaj qis ntawm Borneol no tau xav tias yuav muaj kev nyab xeeb. Txawm li cas los xij, nyob rau hauv cov koob tshuaj siab cais los yog raug mus ntev, Borneol tuaj yeem muaj qee yammuaj peev xwm txaus ntshai thiab cov kev mob tshwm sim, suav nrog:

tawv nqaij khaus

Kab mob ntawm qhov ntswg thiab caj pas

Mob taub hau

xeev siab thiab ntuav

kiv taub hau

Lub teeb-headedness

Ua tsis taus pa

Nrog rau Borneol siab heev, cov tib neeg tuaj yeem ntsib:

Kev tsis xis nyob

Kev ntxhov siab

Inattention

qaug dab peg

Yog tias nqos tau, nws tuaj yeem ua rau muaj kuab lom heev

Nws yog ib qho tseem ceeb kom nco ntsoov tias cov nyiaj tam sim no hauv cannabis tsis zoo li ua rau cov tsos mob no. Kev khaus kuj tsis tshwm sim nrog cov koob tshuaj me me uas siv rau kev ua xua thiab lwm yam teebmeem.
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Ntshiab Cnidii Fructus roj rau tswm ciab thiab xab npum ua lag luam wholesale diffuser tseem ceeb roj tshiab rau reed burner diffusers

Cnidium yog ib tsob nroj uas nyob hauv Suav teb. Nws kuj tau pom nyob hauv Asmeskas hauv Oregon. Cov txiv hmab txiv ntoo, noob, thiab lwm yam nroj tsuag yog siv los ua tshuaj.

Cnidium tau siv nyob rau hauv Cov Tshuaj Suav Tshuaj (TCM) rau ntau txhiab xyoo, feem ntau rau cov tawv nqaij mob. Nws tsis yog qhov xav tsis thoob tias cnidium yog ib qho khoom muaj nyob rau hauv Suav tshuaj pleev, cream, thiab tshuaj pleev.

Cov tib neeg noj cnidium los ntawm qhov ncauj rau kev ua kom muaj kev sib deev thiab kev sib deev, thiab kho erectile kawg (ED). Cnidium kuj tseem siv rau kev nyuaj rau menyuam yaus (kev tsis muaj menyuam), kev tsim lub cev, mob qog noj ntshav, cov pob txha tsis muaj zog (osteoporosis), thiab kab mob fungal thiab kab mob. Qee tus neeg kuj coj nws los ua kom muaj zog.

Cnidium yog siv ncaj qha rau ntawm daim tawv nqaij rau khaus, pob khaus, eczema, thiab ringworm.

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Ntshiab oud Branded naj hoom tshuaj tsw qab roj rau tswm ciab thiab xab npum ua lag luam wholesale diffuser tseem ceeb roj tshiab rau reed burner diffusers

Tshuaj muaj pes tsawg leeg ntawm ATR

Cov tshuaj lom neeg muaj pes tsawg leeg ntawm ATR feem ntau yog cov khoom tsis zoo thiab cov khoom tsis hloov pauv. ATR cov roj tseem ceeb (ATEO) raug suav tias yog cov khoom tseem ceeb ntawm ATR, thiab cov ntsiab lus ntawm ATEO tsuas yog qhov taw qhia rau kev txiav txim siab ntawm ATR cov ntsiab lus. Tam sim no, muaj ntau yam kev tshawb fawb txog qhov tsis hloov pauv thiab tsis tshua muaj kev tshawb fawb ntawm cov khoom tsis hloov pauv. Cov khoom tsis sib haum xeeb yog qhov nyuaj, thiab cov yam ntxwv tseem ceeb yog phenylpropanoids (phenylpropanoids yooj yim, lignans thiab coumarins) thiab terpenoids (monoterpenes, sesquiterpenes, diterpenoids thiab triterpenes). Cov khoom tsis-volatile feem ntau yog alkaloids, aldehydes thiab acids, quinones thiab ketones, sterols, amino acids, thiab carbohydrates. Cov txiaj ntsig ntawm ATR kev tshawb fawb tshuaj muaj pes tsawg leeg yuav pab txhawb kev txhim kho nws cov kev tshawb fawb zoo.

Volatile muaj pes tsawg leeg

Cov kws tshawb fawb tau siv cov txheej txheem kev tshuaj ntsuam xyuas xws li chromatography thiab GC-MS los tshuaj xyuas cov tshuaj lom neeg ntawm ATR los ntawm ntau lub hauv paus, cov khoom sib txawv, cov txheej txheem sib txawv thiab cov khoom sib txawv. Cov kev tshawb fawb yav dhau los tau qhia tias cov khoom siv tshuaj lom neeg tseem ceeb hauv ATR yog cov roj tsis hloov pauv, uas yog qhov taw qhia tseem ceeb rau kev ntsuas qhov zoo ntawm ATR. α-Asarone thiab β-asarone accounted rau 95% ntawm ATR volatile roj thiab raug txheeb xyuas raws li cov yam ntxwv Cheebtsam (Daim duab 1) (Lam et al., 2016a). Lub "Pharmacopoeia ntawm Cov Neeg Lub Tebchaws Suav Tebchaws ntawm Tuam Tshoj" (2020 Tsab) sau tseg tias cov roj tsis hloov pauv ntawm ATR yuav tsum tsis pub tsawg dua 1.0% (mL / g). Tam sim no, ntau hom roj tsis hloov pauv tau pom hauv ATR

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Ntshiab oud Branded naj hoom tshuaj tsw qab roj rau tswm ciab thiab xab npum ua lag luam wholesale diffuser tseem ceeb roj tshiab rau reed burner diffusers

Perilla yog tshuaj ntsuab. Nplooj thiab noob yog siv los ua tshuaj.

Perilla yog siv los kho mob hawb pob. Nws kuj yog siv rau xeev siab, tshav kub hnyiab, inducing tawm hws, thiab txo cov leeg nqaij spasms.

Hauv cov khoom noj, perilla yog siv los ua flavoring.

Hauv kev tsim khoom, perilla noob roj yog siv lag luam hauv kev tsim cov kua roj vanish, dyes, thiab inks.

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Ntshiab oud Branded naj hoom tshuaj tsw qab roj rau tswm ciab thiab xab npum ua lag luam wholesale diffuser tseem ceeb roj tshiab rau reed burner diffusers

Angelica yog tsob ntoo. Hauv paus, noob, thiab txiv hmab txiv ntoo yog siv los ua tshuaj.

Angelica yog siv rau kev kub hnyiab, plab hnyuv (flatulence), tsis qab los noj mov (anorexia), mob caj dab, teeb meem ncig, "kua ntswg" (ua pa catarrh), nervousness, plague, thiab teeb meem pw tsaug zog (insomnia).

Qee cov poj niam siv angelica los pib lawv lub cev xeeb tub. Qee lub sij hawm qhov no ua rau kev rho menyuam.

Angelica kuj tseem siv los ua kom cov zis ntau lawm, txhim kho kev sib deev, txhawb kev tsim tawm thiab tso tawm cov phlegm, thiab tua cov kab mob.

Qee cov neeg siv cov tshuaj angelica ncaj qha rau ntawm daim tawv nqaij rau mob paj hlwb (neuralgia), mob pob qij txha (rheumatism), thiab kab mob ntawm daim tawv nqaij.

Ua ke nrog lwm cov tshuaj ntsuab, angelica kuj yog siv los kho ejaculation ntxov ntxov.

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100% Ntshiab Herbal Essential Cyperus Roj rau Soap Ua Cyperus Rotundus Roj

Nutgrass yog cov tshuaj muaj npe nrov siv thoob plaws ntau hom kev kho tawv nqaij zoo. Raws li Ayurveda, nws tau siv nyob rau hauv ntau yam concoctions uas tau npaj los ua kom pom qhov tsaus ntuj thiab lwm yam.

Cov txiaj ntsig…

Nws kuj tau pom nyob rau hauv ntau cov tshuaj Ayurvedic los kho cov pob khaus, kab mob fungal thiab mob ntawm daim tawv nqaij. Cov hmoov extracts ntawm Nutgrass hauv paus muaj zog heev thiab enriched nrog antioxidants, uas yuav pab kom qeeb ntawm daim tawv nqaij laus raws li nws ua hauj lwm los txo cov kab zoo thiab wrinkles. Nws pab tswj cov txheej txheem ntau dhau ntawm cov xim, melanin, hauv daim tawv nqaij. Li no nws restores brighter complexion ntawm daim tawv nqaij. Nutgrass txias nyob rau hauv cov xwm, nws cov khoom tiv thaiv kab mob pab soothe redness, breakouts, thiab inflamed daim tawv nqaij. Nws tau ua pov thawj los kho cov tawv nqaij mob hnyav. Nws yog nplua nuj nyob rau hauv fatty acids, vitamins thiab flavonoids uas muaj txiaj ntsig zoo rau daim tawv nqaij thiab plaub hau. Cov khoom no ntxiv rau daim tawv nqaij radiance, thiab ntxiv dag zog rau cov plaub hau nrog ci thiab ntim.

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High quality ntshiab natural Notopterygium roj siv rau kev kho mob

Nyob rau hauv cov nqe lus ntawm dispelling cua thiab tshem tawm dampness, muaj ntau yam tsim nyog suav tshuaj ntsuab. Yog li ntawd, piv cov notopterygium nrog nws cov phooj ywg nrog cov khoom zoo sib xws yuav pab peb nkag siab txog cov nroj tsuag tshuaj no zoo dua.

Ob lub hauv paus notopterygium thiab Angelica hauv paus (Du Huo) tuaj yeem tshem cov cua-dawb thiab txhim kho kev mob ntawm pob qij txha thiab txhav. Tab sis lawv muaj lawv tus kheej lub zog thiab tsis muaj zog feem. Cov qub yog nrog cov xwm txheej muaj zog thiab tsw, uas ua rau nws muaj cov nyhuv antipyretic zoo dua los ntawm kev tawm hws thiab nce zog. Vim li ntawd, nws yog ib qho tshuaj ntsuab zoo rau cov kab mob txha caj qaum thiab mob hauv lub cev sab sauv thiab sab nraub qaum. Hauv kev sib piv, angelica hauv paus yog nrog nqis nqis, uas ua rau nws muaj lub zog kho zoo dua ntawm rheumatism ntawm lub cev qis thiab mob pob qij txha hauv ko taw, sab nraub qaum, ceg, thiab ci ntsa iab. Raws li qhov tshwm sim, lawv feem ntau siv hauv khub tshuaj vim tias lawv muaj ntau yam ntxiv.

Ob leeg notopterygium thiabGui Zhi (Ramulus Cinnamomi)yog qhov zoo ntawm kev tshem tawm cua thiab tshem tawm txias. Tab sis qhov qub nyiam cua-dej hauv lub taub hau, caj dab, thiab rov qab thaumGui ZhiNws yog qhov zoo dua los daws cov cua-dej hauv lub xub pwg nyom, caj npab, thiab ntiv tes.

Ob leeg notopterygium thiabFang Feng (Radix Saposhnikoviae)tshwj xeeb ntawm kev tshem tawm cua. Tab sis tus qub muaj zog dua Fang Feng.

Niaj hnub nimno pharmacological kev ua ntawm notopterygium cag

1. Nws txhaj tshuaj muaj analgesic thiab antipyretic teebmeem. Tsis tas li ntawd, nws muaj inhibition ntawm daim tawv nqaij fungus thiab brucellosis;
2. Nws qhov soluble feem muaj kev sim tshuaj tiv thaiv arrhythmic;
3. Nws cov roj volatile kuj muaj anti-inflammatory, analgesic thiab antipyretic teebmeem. Thiab nws tuaj yeem tiv thaiv pituitrin-induced myocardial ischemia thiab nce myocardial khoom noj khoom haus ntshav txaus;
4. Nws cov roj volatile tseem inhibits ncua hom hypersensitivity nyob rau hauv nas.

Piv txwv notopterygium incisum zaub mov txawv ntawm cov tshuaj ntsuab

Zhong Guo Yao Dian (Suav pharmacopoeia) ntseeg hais tias nws yog acrid thiab iab nyob rau hauv tsw thiab sov nyob rau hauv cov xwm. Nws npog meridians ntawm lub zais zis thiab lub raum. Lub luag haujlwm tseem ceeb yog tshem tawm cua, tshem tawm qhov txias, tshem tawm dampness, thiab txo qhov mob. Basic notopterygium siv thiab indications muaj xws limob taub hauhom cua txiasmob khaub thuas, rheumatism, thiab mob ib ce nyob rau hauv lub xub pwg nyom thiab nraub qaum. Cov koob tshuaj pom zoo yog los ntawm 3 mus rau 9 grams.

1. Qiang HuoFu ZiTang los ntawm Yi Xue Xin Wu (Kev Kho Mob Tshwm Sim). Nws ua ke nrog Fu Zi (Aconite),Gan Jiang(Qhuav GingerRoot), thiab ZhiGan Cao(Honey Fried Licorice Root) los kho lub hlwb tawm tsam los ntawm cov kab mob khaub thuas txawv teb chaws, mob hlwb tawg mus rau cov hniav, caj dab txias, thiab cua txias ntawm qhov ncauj thiab qhov ntswg.

2. Jiu Wei Qiang Huo Tang los ntawmCi ShiNan Zhi (Hard-Won Knowledge). Nws yog formulated nrog Fang Feng, Xi Xin (Herba Asari),Chuan Xiong(lovage root), thiab lwm yam los kho cua txias hom kab mob sab nraud nrog dampness, chills, kub taub hau, tsis muaj hws, mob taub hau,caj dab tawv, thiab ntse pob qij txha mob nyob rau hauv nqua.

3. Qiang Huo Sheng Shi Tang los ntawm Nei Wai Shang Bian Huo Lun (Tshaj tawm qhov kev tsis txaus siab txog kev raug mob los ntawm sab hauv thiab sab nrauv). Nws yog siv ua ke nrog angelica hauv paus,Gao Ben(Rhizoma Ligustici), Fang Feng, thiab lwm yam los kho sab nrauv cua-dawb, mob taub hau thiab mob txha nraub qaum, qaub hnyav sab nraub qaum, thiab tag nrho lub cev mob pob qij txha.

4. Juan Bi Tang, tseem hu ua notopterygium thiabturmericua ke, los ntawm Bai Yi Xuan Fang (Precisely-xaiv Tshuaj). Nws ua haujlwm nrog Fang Feng, Jiang Huang (Curcuma Longa),Dang Gui(Dong Quai), thiab lwm yam kom xaus cua-txias-dampness arthralgia nyob rau hauv lub Upper lub cev, mob nyob rau hauv sib koom tes ntawm lub xub pwg nyom thiab ceg.

5. Qiang Huo Gong Gao Tang los ntawm Shen Shi Yao Han (Ib Phau Ntawv Tseem Ceeb ntawmOphthalmology). Nws txuas nrog lovage cag,Bai Zhi(Angelica Dahurica: koj puas xav tau ntau tus thwjtim?), Rhizoma Ligustici, thiab lwm yam rau kev kho mob taub hau los ntawm cua-txias los yog cua-dej.

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Pure Aucklandia lappa roj rau tswm ciab thiab xab npum ua lag luam wholesale diffuser tseem ceeb roj tshiab rau reed burner diffusers

Osteoarthritis (OA) yog ib lub sij hawm ntev degenerative pob txha cov kab mob uas cuam tshuam rau cov neeg laus dua 65 xyoo.1]. Feem ntau, OA cov neeg mob tau kuaj pom tias muaj pob txha mos, mob synovium, thiab chondrocytes eroded, uas ua rau mob thiab mob lub cev [2]. Mob caj dab feem ntau yog tshwm sim los ntawm degeneration ntawm pob txha mos nyob rau hauv cov pob qij txha los ntawm o, thiab thaum cov pob txha mos raug mob hnyav cov pob txha tuaj yeem sib tsoo nrog ib leeg ua rau mob tsis taus thiab mob lub cev [3]. Kev koom tes ntawm inflammatory mediators nrog cov tsos mob xws li mob, o, thiab txhav ntawm lub pob qij txha yog cov ntaub ntawv zoo. Hauv cov neeg mob OA, inflammatory cytokines, uas ua rau kev yaig ntawm pob txha mos thiab cov pob txha subchondral muaj nyob hauv cov kua dej synovial [4]. Ob qhov kev tsis txaus siab loj uas cov neeg mob OA feem ntau muaj yog mob thiab mob synovial. Yog li lub hom phiaj tseem ceeb ntawm kev kho OA tam sim no yog txo qhov mob thiab mob. [5]. Txawm hais tias muaj cov kev kho mob OA, suav nrog cov tshuaj uas tsis yog steroidal thiab steroidal, tau ua pov thawj tias muaj txiaj ntsig zoo hauv kev txo qhov mob thiab mob, kev siv cov tshuaj no mus ntev muaj qhov cuam tshuam rau kev noj qab haus huv xws li mob plawv, plab hnyuv, thiab lub raum tsis ua haujlwm [6]. Yog li, cov tshuaj muaj txiaj ntsig zoo dua nrog cov kev mob tshwm sim tsawg dua yuav tsum tau tsim rau kev kho mob osteoarthritis.

Cov khoom noj qab haus huv tau nrov zuj zus rau kev nyab xeeb thiab yooj yim muaj [7]. Cov tshuaj Kaus Lim Kauslim tau ua pov thawj tias muaj txiaj ntsig tiv thaiv ntau yam kab mob, suav nrog kev mob caj dab [8]. Aucklandia lappa DC. paub txog nws cov khoom siv tshuaj, xws li txhim kho txoj kev ncig ntawm qi rau txo qhov mob thiab soothing lub plab, thiab tau siv ib txwm siv raws li ib qho kev ua kom mob plab [9]. Cov ntaub ntawv dhau los qhia tias A. lappa muaj cov tshuaj tiv thaiv kab mob [10,11], analgesic [12], anticancer [13], thiab gastroprotective [14] teebmeem. Ntau yam kev ua ub no ntawm A. lappa yog tshwm sim los ntawm nws cov ntsiab lus tseem ceeb: costunolide, dehydrocostus lactone, dihydrocostunolide, costuslactone, α-costol, saussurea lactone thiab costuslactone [15]. Cov kev tshawb fawb yav dhau los tau lees tias costunolide tau pom cov khoom tiv thaiv kab mob hauv lipopolysaccharide (LPS), uas ua rau cov macrophages los ntawm kev tswj hwm ntawm NF-kB thiab cov cua sov ua kom muaj protein ntau txoj hauv kev [16,17]. Txawm li cas los xij, tsis muaj kev tshawb fawb tau tshawb xyuas cov dej num muaj peev xwm ntawm A. lappa rau kev kho OA. Cov kev tshawb fawb tam sim no tau tshawb xyuas cov kev kho mob ntawm A. lappa tiv thaiv OA siv (monosodium-iodoacetate) MIA thiab acetic acid-induced nas qauv.

Monosodium-iodoacetate (MIA) yog nto moo siv los tsim ntau yam mob ntawm tus cwj pwm thiab cov yam ntxwv pathophysiological ntawm OA hauv cov tsiaj [18,19,20]. Thaum txhaj rau hauv lub hauv caug pob qij txha, MIA disarrays chondrocyte metabolism thiab induces o thiab inflammatory cov tsos mob, xws li pob txha mos thiab subchondral pob txha erosion, lub cardinal cov tsos mob ntawm OA [18]. Writhing teb induced nrog acetic acid yog dav suav hais tias yog qhov simulation ntawm peripheral mob nyob rau hauv cov tsiaj uas qhov mob inflammatory yuav ntsuas ntau npaum li cas [19]. Tus nas macrophage cell kab, RAW264.7, yog nrov siv los kawm cov cellular teb rau o. Thaum ua haujlwm nrog LPS, RAW264 macrophages qhib txoj hauv kev inflammatory thiab zais ntau yam kab mob sib kis, xws li TNF-α, COX-2, IL-1β, iNOS, thiab IL-6 [20]. Txoj kev tshawb no tau soj ntsuam cov tshuaj tiv thaiv nociceptive thiab anti-inflammatory los ntawm A. lappa tiv thaiv OA hauv MIA tsiaj qauv, acetic acid-induced tsiaj qauv, thiab LPS-activated RAW264.7 hlwb.

2. Cov ntaub ntawv thiab cov txheej txheem

2.1. Cov khoom cog

Cov cag qhuav ntawm A. lappa DC. siv nyob rau hauv qhov kev sim yog procured los ntawm Epulip Pharmaceutical Co., Ltd., (Seoul, Kauslim). Nws raug txheeb xyuas los ntawm Prof. Donghun Lee, Dept. of Herbal pharmacology, Col. ntawm Kauslim Tshuaj, Gachon University, thiab daim ntawv pov thawj tus naj npawb tau muab tso rau hauv 18060301.

2.2. HPLC Kev Ntsuam Xyuas ntawm A. lappa Extract

A. lappa tau muab rho tawm siv lub tshuab reflux (dej distilled, 3 h ntawm 100 ° C). Cov tshuaj tau muab rho tawm tau lim thiab condensed siv lub evaporator uas tsis tshua muaj siab. A. lappa extract muaj cov txiaj ntsig ntawm 44.69% tom qab khov-qhuav hauv qab -80 ° C. Chromatographic tsom xam ntawm A. lappa tau ua nrog HPLC txuas nrog siv 1260 InfinityⅡ HPLC-system (Agilent, Pal Alto, CA, USA). Rau kev sib cais chromatic, EclipseXDB C18 kem (4.6 × 250 mm, 5 µm, Agilent) tau siv ntawm 35 ° C. Tag nrho ntawm 100 mg ntawm cov hnoos qeev tau diluted hauv 10 mL ntawm 50% methanol thiab sonicated rau 10 min. Cov qauv raug lim nrog lub syringe lim (Waters Corp., Milford, MA, USA) ntawm 0.45 μm. Cov theem mobile muaj pes tsawg leeg yog 0.1% phosphoric acid (A) thiab acetonitrile (B) thiab kem tau eluted raws li nram no: 0-60 min, 0%; 60-65 feeb, 100%; 65–67 feeb, 100%; 67-72 min, 0% hnyav B nrog tus nqi ntws ntawm 1.0 mL / min. Cov effluent tau pom ntawm 210 nm siv qhov ntim ntawm 10 μL. Kev tsom xam tau ua nyob rau hauv triplicate.

2.3. Tsiaj Tsev thiab Kev Tswj Xyuas

Txiv neej Sprague-Dawley (SD) nas hnub nyoog 5 lub lis piam thiab txiv neej ICR nas hnub nyoog 6 lub lis piam tau yuav los ntawm Samtako Bio Kauslim (Gyeonggi-do, Kauslim). Tsiaj txhu tau khaws cia rau hauv ib chav uas siv qhov kub thiab txias (22 ± 2 ° C) thiab av noo (55 ± 10%) thiab lub teeb / tsaus voj voog ntawm 12/12 h. Cov tsiaj tau paub txog tus mob rau ntau tshaj ib lub lis piam ua ntej qhov kev sim pib. Tsiaj txhu muaj ad libitum khoom noj thiab dej. Cov kev cai coj ncaj ncees tam sim no rau kev saib xyuas tsiaj thiab tuav ntawm Gachon University (GIACUC-R2019003) tau ua raws li txhua yam kev sim tsiaj. Txoj kev tshawb no tau tsim los ntawm tus kws tshawb nrhiav-dig muag thiab kev sim sib luag. Peb tau ua raws li txoj kev euthanasia raws li cov lus qhia ntawm Pawg Neeg Saib Xyuas Kev Ncaj Ncees Tsiaj.

2.4. MIA Txhaj Tshuaj thiab Kev Kho Mob

Cov nas tsuag tau muab cais ua 4 pawg, xws li sham, tswj, indomethacin, thiab A. lappa. Ua tshuaj loog nrog 2% isofluorane O2 sib tov, cov nas tau txhaj tshuaj siv 50 μL ntawm MIA (40 mg / m; Sigma-Aldrich, St. Louis, MO, USA) intra-articularly rau hauv lub hauv caug pob qij txha los ua rau kev sim OA. Cov kev kho mob tau ua raws li hauv qab no: kev tswj hwm thiab pab pawg sham tsuas yog khaws cia nrog AIN-93G cov zaub mov yooj yim. Tsuas yog, pawg indomethacin tau muab cov tshuaj indomethacin (3 mg / kg) muab tso rau hauv AIN-93G noj zaub mov thiab A. lappa 300 mg / kg pawg tau muab rau AIN-93G noj zaub mov ntxiv nrog A. lappa (300 mg / kg). Cov kev kho mob tau txuas ntxiv rau 24 hnub txij li hnub ntawm OA induction ntawm tus nqi ntawm 15-17 g ib 190-210 g lub cev hnyav rau ib hnub.

2.5. Kev ntsuas qhov hnyav

Tom qab OA induction, qhov hnyav-kev muaj peev xwm ntsuas ntawm hind ceg ntawm cov nas tau ua nrog qhov tsis muaj peev xwm-MeterTester600 (IITC Life Science, Woodland Hills, CA, USA) raws li tau teem tseg. Kev faib tawm qhov hnyav ntawm sab nraub qaum tau suav nrog: qhov hnyav hnyav (%)

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Suav Angelica Dahurica hauv paus Extract Roj rau Massage
Kev siv Angelica

Kev siv ntxiv yuav tsum yog tus kheej thiab soj ntsuam los ntawm tus kws kho mob, xws li tus kws kho mob sau npe, kws muag tshuaj, lossis tus kws kho mob. Tsis muaj tshuaj ntxiv yog npaj los kho, kho, lossis tiv thaiv kab mob.

Cov pov thawj kev tshawb fawb muaj zog txhawb kev siv Angelica tsis muaj. Txog tam sim no, ntau ntawm kev tshawb fawb txogAngelica ntawm archangelicatau ua nyob rau hauv cov qauv tsiaj los yog hauv cov chaw kuaj mob. Raws li tag nrho, kev sim tib neeg xav tau ntau ntxiv ntawm cov txiaj ntsig zoo ntawm Angelica.

Hauv qab no yog saib cov kev tshawb fawb uas twb muaj lawm hais txog kev siv Angelica.

Nocturia

Nocturiayog ib yam mob uas txhais tau hais tias yuav tsum sawv los ntawm kev pw tsaug zog ib los yog ntau zaus txhua hmo kom tso zis. Angelica tau kawm txog nws txoj kev siv los txo qhov nocturia.

Hauv ib txoj kev tshawb nrhiav ob qhov muag tsis pom kev, cov neeg koom nrog nocturia uas tau muab rau txiv neej thaum yug los tau randomized kom tau txais ib qhocov tshuaj placebo(ib yam khoom siv tsis zoo) lossis cov khoom tsim los ntawm covAngelica ntawm archangelicanplooj rau yim lub lis piam.4

Cov neeg koom tau raug nug kom taug qab hauv phau ntawv teev npe thaum lawvtso zis. Cov kws tshawb fawb tau soj ntsuam cov ntawv teev npe ua ntej thiab tom qab lub sijhawm kho. Thaum kawg ntawm txoj kev tshawb no, cov neeg uas coj Angelica tau tshaj tawm tsawg dua qhov tsis muaj dab tsi thaum hmo ntuj (qhov yuav tsum tau sawv ntsug nruab nrab ntawm hmo ntuj kom tso zis) dua li cov neeg siv cov placebo, tab sis qhov txawv tsis tseem ceeb.4

Hmoov tsis zoo, ob peb lwm yam kev tshawb fawb tau ua los txiav txim siab seb Angelica tuaj yeem txhim kho nocturia zoo li cas. Xav tau kev tshawb fawb ntxiv hauv cheeb tsam no.

Mob qog noj ntshav

Txawm tias tsis muaj tshuaj ntxiv lossis tshuaj ntsuab tuaj yeem kho taumob qog noj ntshav, muaj qee qhov kev txaus siab rau Angelica raws li kev kho mob ntxiv.

Cov kws tshawb fawb tau kawm Angelica qhov muaj peev xwm tiv thaiv kab mob qog noj ntshav hauv chav kuaj. Hauv ib qho kev tshawb fawb no, cov kws tshawb fawb tau simAngelica ntawm archangelicaextract raumob cancer mishlwb. Lawv pom tias Angelica tuaj yeem pab ua rau mob qog noj ntshav ntawm lub mis tuag, ua rau cov kws tshawb fawb txiav txim siab tias cov tshuaj ntsuab yuav muajantitumormuaj peev xwm.5

Ib txoj kev tshawb fawb qub uas tau ua rau cov nas pom tau zoo sib xws.6 Txawm li cas los xij, cov txiaj ntsig no tsis tau muab luam tawm hauv tib neeg kev sim. Yog tsis muaj tib neeg sim, tsis muaj pov thawj tias Angelica tuaj yeem pab tua tib neeg cov qog nqaij hlav cancer.

Kev ntxhov siab

Angelica tau siv rau hauv cov tshuaj ib txwm siv los khokev ntxhov siab. Txawm li cas los xij, pov thawj kev tshawb fawb los txhawb qhov kev thov no tsis tshua muaj.

Raws li nrog rau lwm yam kev siv ntawm Angelica, kev tshawb fawb ntawm nws txoj kev siv nyob rau hauv kev ntxhov siab feem ntau tau ua nyob rau hauv lub chaw kuaj mob los yog nyob rau hauv cov tsiaj qauv.

Hauv ib txoj kev tshawb fawb, Angelica extracts tau muab rau nas ua ntej lawv yuav tsum uakev ntxhov siabkuaj. Raws li cov kws tshawb fawb, nas ua tau zoo dua tom qab tau txais Angelica, ua rau nws muaj peev xwm kho tau kev ntxhov siab.7

Tib neeg kev sim siab thiab kev tshawb fawb hnyav dua yuav tsum tau txiav txim siab Angelica lub luag haujlwm muaj peev xwm los kho kev ntxhov siab.

Antimicrobial Properties

Angelica tau hais tias muaj cov tshuaj tua kab mob, tab sis kev tshawb fawb tib neeg zoo tsis tau ua los ua pov thawj qhov kev thov no.

Raws li qee cov kws tshawb fawb, Angelica nthuav tawm cov tshuaj tiv thaiv kab mob tiv thaiv: 2

Clostridium difficile (C. sib)

Clostridium perfringens

Enterococcus faecalis

Eubacterium limosum

Peptostreptococcus anaerobius

Candida albicans

Txawm li cas los xij, cov ntsiab lus me me tau muab hais txog yuav ua li cas Angelica tuaj yeem cuam tshuam cov kab mob no thiab lwm yam kab mob thiab cov kab mob.

Lwm yam kev siv

Hauv cov tshuaj ib txwm siv,Angelica ntawm archangelicayog siv los kho cov mob ntxiv, suav nrog: 1

Insomnia

Cov kab mob digestive

Kab mob ntawm daim tawv nqaij

Cov mob ua pa

Mob caj dab

Cov pov thawj scientific zoo txhawb kev siv cov no tsuas yog txwv. Nco ntsoov tham nrog tus kws kho mob ua ntej siv Angelica rau cov no thiab lwm yam mob.

Dab tsi yog qhov cuam tshuam ntawm Angelica?

Raws li nrog txhua yam tshuaj ntsuab lossis ntxiv, Angelica tuaj yeem ua rau muaj kev phiv. Txawm li cas los xij, vim tsis muaj kev sim tib neeg, muaj ob peb cov lus ceeb toom ntawm qhov ua tau tshwm sim ntawm Angelica.
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Ntshiab natural organic magnolia tseem ceeb roj flos magnoliae roj rau naj hoom roj

Magnoliae Flos yog cov khoom siv tshuaj niaj hnub siv hauv Asia. Nws yog siv los kho sinusitis, qhov ntswg congestion, thiab hypersensitive ntawm daim tawv nqaij. Vim tias Magonlia Flos tau piav qhia tias yog cov khoom muaj ntxhiab hauv cov ntawv Suav thaum ub, peb xav tias nws cov roj tseem ceeb yuav raug siv los kho cov kab mob tiv thaiv kab mob. Dendritic cells (DCs), suav tias yog lub hom phiaj tseem ceeb ntawm cov tshuaj tiv thaiv kab mob los tswj cov kab mob tiv thaiv kab mob, ua lub luag haujlwm tseem ceeb hauv kev hloov lub cev tiv thaiv kab mob. Hauv txoj kev tshawb no, Magnoliae Flos tseem ceeb roj (MFEO) txo qis kev tsim cov cytokines TNF- α, IL-6, thiab IL-12p70 hauv lipopolysaccharide (LPS)-stimulated DCs. Nws kuj tseem txwv cov cim saum npoo MHC II, CD80, thiab CD86 hauv LPS-stimulated DCs. Cov qauv tsiaj tau pom tias 2,4-Dinitro-1-fluorobenzene (DNFB) ua rau muaj kev sib cuag nrog cov lus teb tau raug cuam tshuam tom qab kev kho mob nrog MFEO. Tsis tas li ntawd, MFEO inhibited infiltration ntawm T hlwb nyob rau hauv pob ntseg ntawm DNFB-induced nas. Txhawm rau tshawb xyuas nws cov bioactive compounds, cov khoom ntawm MFEO tau txheeb xyuas siv cov roj chromatography (GC) thiab GC-mass spectrometry. Cov txiaj ntsig tau qhia tias cov ntsiab lus tseem ceeb hauv MFEO yog camphor thiab 1,8-cineole. Ntxiv DC bioassays tau lees paub tias cov khoom sib txuas no ua rau muaj kev cuam tshuam cov cytokine ntau lawm hauv LPS-induced DCs. Yog li, peb tau pom tias MFEO nthuav tawm cov tshuaj tiv thaiv kab mob ob qho tib si hauv vivo thiab hauv vitro, thiab camphor thiab 1,8-cineole tej zaum yuav yog lub luag haujlwm tseem ceeb rau nws lub peev xwm tiv thaiv kab mob. Cov kev tshawb pom qhia tias MFEO muaj peev xwm tsim los ua ib qho tshuaj tiv thaiv kab mob tshiab rau cov kab mob ntau dhau.

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